The role of CD45 and CD45 | 合法醫療器材資訊網
由JGAltin著作·1997·被引用215次—CD45(lymphocytecommonantigen)isareceptor-linkedproteintyrosinephosphatasethatisexpressedonallleucocytes,andwhichplaysacrucialrolein ...
CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells. On T cells the extracellular domain of CD45 is expressed in several different isoforms, and the particular isoform(s) expressed depends on the particular subpopulation of cell, their state of maturation, and whether or not they have previously been exposed to antigen. It has been established that the expression of CD45 is essential for the activation of T cells via the TCR, and that different CD45 isoforms display a different ability to support T cell activation. Although the tyrosine phosphatase activity of the intracellular region of CD45 has been shown to be crucial for supporting signal transduction from the TCR, the nature of the ligands for the different isoforms of CD45 have been elusive. Moreover, the precise mechanism by which ...
CD45 and the immune response | 合法醫療器材資訊網
CD45 in immune cell regulation | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45isotypes expression in the immune cells of human ... | 合法醫療器材資訊網
Innate immune cell CD45 regulates lymphopenia | 合法醫療器材資訊網
Modulation of immune cell signalling by the leukocyte ... | 合法醫療器材資訊網
The CD45 tyrosine phosphatase | 合法醫療器材資訊網
The role of CD45 and CD45 | 合法醫療器材資訊網
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