CD45 | 合法醫療器材資訊網
由MLHermiston著作·2003·被引用897次—StudiesofCD45mutantcelllines,CD45-deficientmice,andCD45-deficienthumansinitiallydemonstratedtheessentialroleofCD45inantigenreceptorsignal ...
Regulation of tyrosine phosphorylation is a critical control point for integration of environmental signals into cellular responses. This regulation is mediated by the reciprocal actions of protein tyrosine kinases and phosphatases. CD45, the first and prototypic receptor-like protein tyrosine phosphatase, is expressed on all nucleated hematopoietic cells and plays a central role in this process. Studies of CD45 mutant cell lines, CD45-deficient mice, and CD45-deficient humans initially demonstrated the essential role of CD45 in antigen receptor signal transduction and lymphocyte development. It is now known that CD45 also modulates signals emanating from integrin and cytokine receptors. Recent work has focused on regulation of CD45 expression and alternative splicing, isoform-specific differences in signal transduction, and regulation of phosphatase activity. From these studies, a model is emerging in which CD45 af...
CD45 and the immune response | 合法醫療器材資訊網
CD45 in immune cell regulation | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45isotypes expression in the immune cells of human ... | 合法醫療器材資訊網
Innate immune cell CD45 regulates lymphopenia | 合法醫療器材資訊網
Modulation of immune cell signalling by the leukocyte ... | 合法醫療器材資訊網
The CD45 tyrosine phosphatase | 合法醫療器材資訊網
The role of CD45 and CD45 | 合法醫療器材資訊網
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