Modulation of immune cell signalling by the leukocyte ... | 合法醫療器材資訊網
由AESaunders著作·2010·被引用164次—CD45isaleukocytespecifictransmembraneglycoproteinandareceptor-likeproteintyrosinephosphatase(PTP).CD45canbeexpressedasseveral ...
CD45 is a leukocyte specific transmembrane glycoprotein and a receptor-like protein tyrosine phosphatase (PTP). CD45 can be expressed as several alternatively spliced isoforms that differ in the extracellular domain. The isoforms are regulated in a cell type and activation state-dependent manner, yet their function has remained elusive. The Src family kinase members Lck and Lyn are key substrates for CD45 in T and B lymphocytes, respectively. CD45 lowers the threshold of antigen receptor signalling, which impacts T and B cell activation and development. CD45 also regulates antigen triggered Fc receptor signalling in mast cells and Toll-like receptor (TLR) signalling in dendritic cells, thus broadening the role of CD45 to other recognition receptors involved in adaptive and innate immunity. In addition, CD45 can affect immune cell adhesion and migration and can modulate cytokine production and signalling. Here we rev...
CD45 and the immune response | 合法醫療器材資訊網
CD45 in immune cell regulation | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
CD45isotypes expression in the immune cells of human ... | 合法醫療器材資訊網
Innate immune cell CD45 regulates lymphopenia | 合法醫療器材資訊網
Modulation of immune cell signalling by the leukocyte ... | 合法醫療器材資訊網
The CD45 tyrosine phosphatase | 合法醫療器材資訊網
The role of CD45 and CD45 | 合法醫療器材資訊網
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