Retinal regeneration by transplantation of retinal tissue ... | 合法醫療器材資訊網

由HShirai著作·2016·被引用5次—Retinalregenerationbytransplantationofretinaltissuederivedfromhumanembryonicorinducedpluripotentstemcells·Abstract·Background.

The retina is composed of three layers of neurons, with photoreceptor cells located in the outermost layer. There are two types of photoreceptors, rods and cones, which respond to light and transfer signals to the inner neurons (Fig. 1a). Retinitis pigmentosa (RP) is a genetic disease characterized by the progressive loss of rod photoreceptors followed by secondary degeneration of cone photoreceptors, with more than 45 causal genes reported to date [1, 2]. However, only a limited number of effective treatments are currently available for this disease. Recently, photoreceptor transplantation therapy has been attracting increasing interest in the field of translational research for patients with RP (Fig. 1b). This interest stems from the first clinical trial using human retinal pigment epithelium derived from human induced pluripotent stem cells (hiPSCs), which was transplanted into the eye of a patient with advanced age-related macular degeneration [3]. Rodent studies have also demon...