Coagulase Test: Principle | 合法醫療器材資訊網

2012年4月18日—CoagulasetestisusedtodifferentiateStaphylococcusaureus(positive)fromCoagulase-negativestaphylococci(CoNS).Coagulaseisan ...

By Acharya Tankeshwar •  Updated: 07/25/22 •  7 min read

The coagulase test helps to identify Staphylococcus aureus which produces the enzyme coagulase (coagulates) plasma from coagulase-negative staphylococci (CONS). Coagulase is also the virulence factor of S. aureus, It converts soluble fibrinogen in plasma to insoluble fibrin, and the fibrin coat the bacterial cells making protecting them from opsonization and phagocytosis. Staphylococcus aureus produces two forms of coagulase, bound and free; [1][2]

Slide coagulase test is done to detect “bound coagulase” or “clumping factor”. The clumping factor is a fibrinogen binding cell surface receptor present ...