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Thecoagulaseslidetestisusedtoidentifythepresenceofboundcoagulaseorclumpingfactor,whichisattachedtothecellwallsofthebacteria.Bound ...

Coagulase Test

The coagulase test identifies whether an organism produces the exoenzyme coagulase, which causes the fibrin of blood plasma to clot. Organisms that produce catalase can form protective barriers of fibrin around themselves, making themselves highly resistant to phagocytosis, other immune responses, and some other antimicrobial agents.

The coagulase slide test is used to identify the presence of bound coagulase or clumping factor, which is attached to the cell walls of the bacteria. Bound coagulase reacts with the fibrinogen in plasma, causing the fibrinogen to precipitate. This causes the cells to agglutinate, or clump together, which creates the “lumpy” look of a positive coagulase slide test.  You may need to place the slide over a light box to observe the clumping of cells in the plasma.

The coagulase t...