Progesterone Receptor - IHC Primary Antibodies | 合法醫療器材資訊網
Antigen Background
The human progesterone receptor (PR) is expressed as two
isoforms, PRA (94 kD) and PRB (114 kD), which function as
ligand-activated transcription factors. These two isoforms are
transcribed from distinct estrogen receptor (ER)-inducible
promoters within a single copy PR gene.
The PRA form is a truncated version of the PRB form, lacking the first 164 N-terminal amino acids. In humans, PRA acts as a transdominant repressor of the transcriptional activity of PRB, glucocorticoid receptor, ER, androgen receptor and mineralocorticoid receptor.PRB functions mainly as a transcriptional activator. PRB is expressed strongly in endometrial glandular and stromal nuclei in the proliferative phase of the menstrual cycle and weakly during the secretory phase and early pregnancy.
Product Specific Information Clone 16 is specific for a region of the N-terminus of the A form of PR. The precise epitope has ...
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Novocastra™ Liquid Mouse Monoclonal Antibody Endothelial ... | 合法醫療器材資訊網
Novocastra™ Liquid Mouse Monoclonal Antibody Progesterone ... | 合法醫療器材資訊網
Progesterone Receptor - IHC Primary Antibodies | 合法醫療器材資訊網
相關資訊整理
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