Rheological Properties of Commercially Available Hyaluronic ... | 合法醫療器材資訊網

由MNicholls著作·2018·被引用16次—MonoviscandOrthovischadmolecularweightsof1000to2900kDa,(ofthesolubleportionforMonovisc),andEuflexxawas2400to3600kDa.Synvisc/ ...

The inconsistent results within the current literature regarding the efficacy of intra-articular-hyaluronic acid (IA-HA) for the treatment of knee osteoarthritis (OA) have been suggested to be due to intrinsic differences between individual HA products. The purpose of this investigation is to define the rheological differences between currently available HA products in the United States at the time of this study for the treatment of knee OA, which will help elaborate on the appropriateness of classifying HA products as a class opposed to as individual agents.

The rheological parameters for Euflexxa, Orthovisc, Supartz, Monovisc, Synvisc, Synvisc-One, Gel-One, and Hyalgan were obtained with a TA AR 2000 EX Rheometer with a cone-plate geometry (40-mm plate diameter and a 2° cone angle) at room temperature.

The bulk rheological parameters of the different products suggest molecular structures traversing the range of dilute solution (Hya...