The Amide Local Anesthetic Lidocaine in Cancer Surgery ... | 合法醫療器材資訊網

由TNChamaraux-Tran著作·2017·被引用50次—TheAmideLocalAnestheticLidocaineinCancerSurgery-PotentialAntimetastaticEffectsandPreservationofImmuneCellFunction?ANarrative ...

Surgical removal of the primary tumor in solid cancer is an essential component of the treatment. However, the perioperative period can paradoxically lead to an increased risk of cancer recurrence. A bimodal dynamics for early-stage breast cancer recurrence suggests a tumor dormancy-based model with a mastectomy-driven acceleration of the metastatic process and a crucial role of the immunosuppressive state during the perioperative period. Recent evidence suggests that anesthesia could also influence the progress of the disease. Local anesthetics (LAs) have long been used for their properties to block nociceptive input. They also exert anti-inflammatory capacities by modulating the liberation or signal propagation of inflammatory mediators. Interestingly, LAs can reduce viability and proliferation of many cancer cells in vitro as well. Additionally, retrospective clinical trials have suggested that regional anesthesi...