Local anesthetic agents | 合法醫療器材資訊網

2021年5月17日—Localanesthetics(LAs)aredrugsthatblockthesensationofpainintheregionwheretheyare...todrugsoftheamidegroup.

Last updated: September 11, 2023

Local anesthetics[1] (LAs) are drugs[2] that block the sensation of pain[3] in the region where they are administered. LAs act by reversibly blocking the sodium[4] channels of nerve fibers, thereby inhibiting the conduction of nerve impulses. Nerve fibers that carry pain[5] sensation have the smallest diameter and are the first to be blocked by LAs. Loss of motor function and sensation of touch and pressure follow, depending on the duration of action and dose of the LA used. LAs can be infiltrated into skin[6]/subcutaneous tissues to achieve local anesthesia[7] or into the epidural/subarachnoid space[8] to achieve regional anesthesia[9] (e.g., spinal anesthesia[10], epidural anesthesia[11]). ...