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由GHLo著作·2003·被引用612次—Basedonthefindingsofthismeta-analysis,intra-articularhyaluronicacidhas,atbest,modestefficacyinthetreatmentofkneeOA.Thiseffectis ...

Context Intra-articular hyaluronic acid is a US Food and Drug Administration–approved treatment for knee osteoarthritis (OA); however, its efficacy is controversial.

Objective To evaluate whether intra-articular hyaluronic acid is efficacious in treating knee OA.

Data Sources We searched for human clinical trials in MEDLINE (1966 through February 2003) and the Cochrane Controlled Trials Register, using the search terms (osteoarthritis, osteoarthrosis, or degenerative arthritis) and (hyaluronic acid, Hyalgan, Synvisc, Artzal, Suplasyn, BioHy, or Orthovisc). We also hand searched manuscript bibliographies that met inclusion criteria, selected rheumatic disease journals, and abstracts from scientific meetings.

Study Selection Included were published or unpublished, English and non-English, single- or double-blinded, randomized controlled tria...