Fluticasone furoate nasal spray | 合法醫療器材資訊網

由HBKaiser著作·2007·被引用190次—Fluticasonefuroatenasalspray:asingletreatmentoptionforthesymptomsofseasonalallergicrhinitis.JAllergyClinImmunol.2007Jun;119(6):1430-7.

Background: Fluticasone furoate (USAN-approved name) is a novel, enhanced-affinity glucocorticoid administered in a unique side-actuated device for the management of seasonal allergic rhinitis (SAR).

Objective: We sought to evaluate the efficacy and safety of once-daily fluticasone furoate nasal spray, 110 microg, in patients aged 12 years or older with fall SAR.

Methods: Patients (n = 299) received fluticasone furoate or placebo for 2 weeks in this double-blind, parallel-group randomized study. Patients evaluated nasal and ocular symptoms using a 4-point categoric scale. Efficacy was assessed on the basis of the mean change from baseline in reflective and instantaneous total nasal symptom scores and reflective total ocular symptom scores.

Results: Fluticasone furoate produced significantly greater improvements than placebo in daily reflective total nasal symptom score ...