Avamys 27.5 microgramsspray | 合法醫療器材資訊網

Fluticasonefuroateisasynthetictrifluorinatedcorticosteroidthatpossessesaveryhighaffinityfortheglucocorticoidreceptorandhasapotentanti- ...

Pharmacotherapeutic group: Nasal preparations, corticosteroids. ATC code: R01AD12

Mechanism of action

Fluticasone furoate is a synthetic trifluorinated corticosteroid that possesses a very high affinity for the glucocorticoid receptor and has a potent anti-inflammatory action.

Clinical efficacy and safety

Seasonal Allergic Rhinitis in adults and adolescents

Compared with placebo, fluticasone furoate nasal spray 110 micrograms once daily significantly improved nasal symptoms (comprising rhinorrhoea, nasal congestion, sneezing and nasal itching) and ocular symptoms (comprising itching/burning, tearing/watering and redness of the eyes) in all 4 studies. Efficacy was maintained over the full 24-hours dosing period with once daily administration.

Onset of therapeutic benefit was observed as early as 8 hours after initial administration,...