Lansoprazole triple therapy for Helicobacter pylori | 合法醫療器材資訊網

由HJO'Connor著作·1998·被引用21次—Five-daylansoprazoletripletherapyisaneffectiveregimenforH.pyloriinfectionwhichcombinesahighcurerateandulcerhealingefficacywiththeadvantages ...

Background: Seven-day proton pump inhibitor triple therapy is currently the treatment of choice for Helicobacter pylori infection. It is unclear whether triple therapy for less than 7 days might preserve efficacy while at the same time improving patient acceptability and compliance.

Aim: To evaluate the Helicobactericidal efficacy, ulcer healing capacity and patient acceptability of a 5-day lansoprazole-based triple therapy regimen.

Methods: Sixty-nine consecutive patients with H. pylori-positive peptic ulcer received lansoprazole 30 mg twice daily in combination with metronidazole 400 mg twice daily and clarithromycin 250 mg twice daily for 5 days. Ulcer healing medication was not continued after the 5-day regimen. H. pylori status was assessed before and at least 4 weeks after therapy by rapid urease test and histology. Adverse events and compliance were assessed by direct que...