Triple vs. quadruple therapy for treating Helicobacter pylori ... | 合法醫療器材資訊網

Background: Triple therapy (proton pump inhibitor, clarithromycin and amoxicillin or an imidazole) is the first-line treatment for Helicobacter pylori infection. However, the effectiveness of triple therapy is decreasing due to the increase in antibiotic resistance. Quadruple therapy (proton pump inhibitor, tetracycline, metronidazole and a bismuth salt) is a very effective regimen even in areas of high prevalence of antibiotic resistance, and may be an alternative first-line treatment.

Aim: To compare triple vs. quadruple therapy for the first-line treatment of H. pylori infection.

Methods: An extensive literature search was performed to identify randomized trials comparing ...