Simulated infusion of paclitaxel with in | 合法醫療器材資訊網

由IBononi著作·2011·被引用2次—Background:Paclitaxelisoneofthemosteffectiveanticancerdrugseverdeveloped.Topreventhazardsassociatedwithintravenous(IV) ...

Background: Paclitaxel is one of the most effective anticancer drugs ever developed. To prevent hazards associated with intravenous (IV) administration which include the formation of microbubbles, microbiological contamination and particulate matter, the suppliers recommend that an in-line IV filter should be used during the infusion of the chemotherapeutic agent.

Methods: To rule out the possibility that polyethersulfone (PES) membranes retain the paclitaxel during filtration, we carried out specific tests. Paclitaxel retention by PES in-line IV filters was evaluated by a simulated-drug IV infusion and high-performance liquid chromatography analysis.

Results: In our model of study, no variation of paclitaxel concentration was revealed before and after filtration using two different filter devices.

Conclusions: The results suggest that, under our experimental conditions...