Plasticizer extraction of Taxol infusion solution from various ... | 合法醫療器材資訊網

由BMass著作·1996·被引用19次—TaxolsolutionextractstheplasticizerDEHP(di(2-ethylhexyl)phthalate)from...thesuitabilityofvariousadministration-andin-linefilter-setsforTaxolapplication.

Taxol solution extracts the plasticizer DEHP (di(2-ethylhexyl)phthalate) from polyvinyl chloride (PVC) materials. In order to minimize patient exposure to DEHP, Taxol solutions should be prepared and administered in PVC-free materials. Particulate matter may form in Taxol infusion solution over time, so that in-line filtration with microporous membranes not greater than 0.22 microns is advisable. The purpose of this study was to evaluate the suitability of various administration- and in-line filter-sets for Taxol application. The extent of leached DEHP was determined using a Reversed Phase HPLC assay specific for DEHP. The four tested administration-sets, labeled as PVC-free, were all found to be suitable for Taxol application. The tested standard PVC-lined administration-set should not be used for Taxol application. Baxter Intermate LV 250 can be recommended as a disposable infusion device for ambulatory Taxol appl...