Cystatin C vs creatinine as markers of renal function in ... | 合法醫療器材資訊網

由PHallberg著作·2004·被引用25次—SerumcystatinChasbeensuggestedtobesuperiortocreatinineforestimationofGFR,whichmayhaverelevancefortheoptimizationoftreatmentwithdigoxin.

Background: The kidney function is a major determinant of the serum concentration of digoxin as this drug is mainly eliminated unchanged through the kidneys. Since digoxin is widely prescribed among the elderly, and the glomerular filtration rate (GFR) declines with age, it is important that the clinician takes the patients GFR into account when prescribing digoxin. Serum cystatin C has been suggested to be superior to creatinine for estimation of GFR, which may have relevance for the optimization of treatment with digoxin.

Methods: To evaluate which of the two GFR markers serum creatinine and serum cystatin C that best correlates with serum digoxin, we compared the serum levels of digoxin with the serum levels of creatinine and cystatin C in 149 patients on therapeutic drug monitoring of digoxin at our hospital.

Results: Overall, there was a stronger correlation between serum digox...