Radioembolization with Yttrium | 合法醫療器材資訊網

由MSBhangoo著作·2015·被引用45次—RadioembolizationisadirectedtechniquethatutilizesmicrospheresembeddedwithYttrium-90(Y-90)intobranchesofthehepaticartery.Y-90isapure ...

The goal of radioembolization is to deliver tumoricidal doses of radiation within the tumor capillary bed, sparing uninvolved liver tissue. Conventional external beam radiation is limited by the extreme radiosensitivity of liver parenchyma (21). Radioembolization takes advantage of the unique vascular supply of the liver and hepatic solid tumors. Liver tumors, in contrast to normal liver parenchyma, derive 80% to 100% of their blood supply from the hepatic artery (22,23). Microspheres embedded with Y-90, when installed through the hepatic artery, concentrate in liver tumors in a 3:1 to 20:1 ratio in comparison to normal liver parenchyma. Radioembolization with Y-90 microspheres has been found to deliver highly effective radiation doses (100 to 1,000+ Gy) to tumor tissue (24).

Our experience adds to the growing body of evidence suggesting that intra-arterial radioemboli...