Deoxyribonuclease I | 合法醫療器材資訊網

DeoxyribonucleaseI(usuallycalledDNaseI),isanendonucleaseoftheDNasefamilycodedbythehumangeneDNASE1.DNaseIisanucleasethatcleaves ...

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Protein-coding gene in the species Homo sapiens

Deoxyribonuclease I (usually called DNase I), is an endonuclease of the DNase family coded by the human gene DNASE1.[5] DNase I is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5-phosphate-terminated polynucleotides with a free hydroxyl group on position 3, on average producing tetranucleotides. It acts on single-stranded DNA, double-stranded DNA, and chromatin. In addition to its role as a waste-management endonuclease, it has been suggested to be one of the deoxyribonucleases responsible for DNA fragmentation during apoptosis.[6]

DNase I binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity...