mdm2 inhibitor nutlin | 合法醫療器材資訊網
由EDrakos著作·2011·被引用61次—p53isfrequentlywildtype(wt)indiffuselargeB-celllymphoma(DLBCL)associatedwitht(14;18)(q32;q21)thatoverexpressesBCL2.Nutlin-3aisasmall ...,由KKojima著作·2006·被引用269次—Nutlinsarepotentandselectivesmall-moleculeantagonistsofMdm2thatbindMdm2inthep53-bindingpocketandactivatethep53pathwayincellswithwild- ...,由KKojima著作·2006·被引用269次—Weinvestigatedthepotentialtherapeuticuseofnongenotoxicp53activationbyasmall-moleculeantagonistofMdm2,Nutlin-3a,inCLL.Nut…,由BWa...
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Activation of the p53 pathway by the MDM2 inhibitor nutlin | 合法醫療器材資訊網
由 E Drakos 著作 · 2011 · 被引用 61 次 — p53 is frequently wild type (wt) in diffuse large B-cell lymphoma (DLBCL) associated with t(14;18)(q32;q21) that overexpresses BCL2. Nutlin-3a is a small ... Read More
Mdm2 inhibitor Nutlin-3a induces p53-mediated ... | 合法醫療器材資訊網
由 K Kojima 著作 · 2006 · 被引用 269 次 — Nutlins are potent and selective small-molecule antagonists of Mdm2 that bind Mdm2 in the p53-binding pocket and activate the p53 pathway in cells with wild- ... Read More
Mdm2 inhibitor Nutlin-3a induces p53 | 合法醫療器材資訊網
由 K Kojima 著作 · 2006 · 被引用 269 次 — We investigated the potential therapeutic use of nongenotoxic p53 activation by a small-molecule antagonist of Mdm2, Nutlin-3a, in CLL. Nut … Read More
MDM2 inhibitor Nutlin | 合法醫療器材資訊網
由 B Wang 著作 · 2012 · 被引用 53 次 — Nutlin-3a is a small-molecule inhibitor that inhibits MDM2 binding to p53 and subsequent p53-dependent DNA damage signaling. In this study, we determined the ... Read More
MDM2X inhibitors under clinical evaluation | 合法醫療器材資訊網
由 V Tisato 著作 · 2017 · 被引用 163 次 — The MDM2 gene codifies for an E3 ubiquitin ligase that acts as a powerful inhibitor of the tumor suppressor P53, the master regulator of the cell ... Read More
Potent in vitro and in vivo antitumor effects of MDM2 inhibitor ... | 合法醫療器材資訊網
由 S Endo 著作 · 2011 · 被引用 51 次 — Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells. Cancer Sci. 2011 Mar;102(3):605-13. doi: 10.1111/j ... Read More
Small-Molecule Inhibitors of the MDM2 | 合法醫療器材資訊網
由 S Shangary 著作 · 2009 · 被引用 623 次 — The Nutlins are the first examples of potent and specific inhibitors of the MDM2-p53 interaction and one of them, Nutlin-3, has been extensively evaluated for its ... Read More
The MDM2 inhibitor Nutlins as an innovative therapeutic tool ... | 合法醫療器材資訊網
由 P Secchiero 著作 · 2008 · 被引用 104 次 — Recently, potent and selective small-molecule MDM2 inhibitors, the Nutlins, have been identified. Studies with these compounds have strengthened the concept ... Read More
The MDM2 | 合法醫療器材資訊網
由 C Deben 著作 · 2015 · 被引用 57 次 — The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer. Oncotarget. Read More
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