The cell proliferation antigen Ki | 合法醫療器材資訊網
由MSobecki著作·2016·被引用161次—AntigenKi-67,whichiswidelyusedasacellproliferationmarker,controls...(A)Top:cartoonofhuman(longform)andmouseKi-67protein...ofnearly400kDa,andnoantibodiesareavailableagainsttheN-ter
Ki-67 has long been assumed to be essential for cell proliferation (Schluter et al., 1993[1]; Kausch et al., 2003[2]; Starborg et al., 1996[3]; Rahmanzadeh et al., 2007[4]; Zheng et al., 2006[5]; 2009[6]). Using various genetic and knockdown approaches, we found no evidence for this in any cell type we tested: HeLa, U2OS, BJ-hTERT and NIH-3T3 fibroblasts. Our data show that Ki-67 expression can be uncoupled from cell proliferation in both directions. Indeed, not only can cells lacking Ki-67 proliferate efficiently, conversely, interfering with Ki-67 downregulation by disrupting the Cdh1 gene did not prevent cell cycle exit in vivo. It remains possible that certain cell lines are more sensitive to inhibition of Ki-67 expression, eg cancer cell lines of bladder (Kausch et al., 2003[7]) or renal (Zheng et al., 2006[8]; 2009[9]) origins. Alternatively, off-target effects of previous...
"達克" Ki | 合法醫療器材資訊網
"達克" Ki | 合法醫療器材資訊網
Detection of markers of cell proliferation by immunofluorescent ... | 合法醫療器材資訊網
Epithelial | 合法醫療器材資訊網
Functional analysis of the proliferation antigen | 合法醫療器材資訊網
The cell proliferation antigen Ki | 合法醫療器材資訊網
The cell proliferation antigen Ki-67 organises ... | 合法醫療器材資訊網
The cell proliferation antigen Ki | 合法醫療器材資訊網
The cell proliferation antigen Ki | 合法醫療器材資訊網
【"達克" Ki-67單株抗體 (未滅菌)】許可證字號:衛部醫器輸壹字第017849號
器材品名:"達克"Ki-67單株抗體(未滅菌)許可證字號:衛部醫器輸壹字第017849號註銷狀態:註銷日期:註銷理由:有效日期:2022/05/1...