Product in indole detection by Ehrlich's reagent | 合法醫療器材資訊網
Ehrlichs reagent (p-dimethylaminobenzaldehyde [DMAB, 1] in 95% EtOH with HCl as catalyst) was employed in spot tests of indoles, providing a diagnosis of, for example, liver diseases, hemolytic processes, occlusion of the common bile duct, and carcinoid syndrome. Although the reagent has been widely used for more than a century, it is not clear how many indole molecules react with a DMAB molecule and whether the reaction takes place at the α- or β-position of the indole molecule. Research here shows that the reaction of DMAB (1) with indole (2) in a 1:2 ratio gives β-bis(indolyl)methane (3). The reaction occurs at the β-position of indole under the conditions of the Ehrlich test, as confirmed by the crystal structure of 3.
Keywords: Ehrlich reaction; Indole; β-Position of indole.
22461300 | 合法醫療器材資訊網
Ehrlich's Aldehyde Reagent | 合法醫療器材資訊網
Ehrlich's reagent | 合法醫療器材資訊網
Ehrlich's Reagent Solution | | 合法醫療器材資訊網
INDOLE (EHRLICH'S) | 合法醫療器材資訊網
INDOLE (EHRLICH'S) | 合法醫療器材資訊網
Product in indole detection by Ehrlich's reagent | 合法醫療器材資訊網
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藥品一覽 | 合法醫療器材資訊網
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