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2020年4月30日—Alpha-1antitrypsindeficiency(AATdeficiency)isaninheritedconditionthatraisesyourriskforlungandliverdisease.

Alpha-1 antitrypsin deficiency (AAT deficiency, or AATD) is an inherited condition that raises your risk for lung[1] and liver[2] disease. If you have this condition, your body doesnt make enough alpha-1 antitrypsin (AAT).

AAT is made by your liver. It helps protect your lungs from inflammation and irritating substances you might breathe in, such as smoke. If your liver doesnt make enough AAT, your lungs may be more easily damaged from smoking[3], pollution[4], or dust from the environment. This can lead to a serious lung condition called chronic obstructive pulmonary disease (COPD[5]). AAT deficiency may also cause a liver disease called cirrhosis[6]. This is more common in children who have AAT deficiency.

AAT deficiency is a genetic disorder[7]. That means its caused by changes in your genes, which may also be called gene variants or mutations.