Physiology, Prolactin | 合法醫療器材資訊網

由MAl-Chalabi著作·2020·被引用10次—Prolactinreleasehasaninhibitoryeffectonthereleaseofgonadotropin-releasinghormone(GnRH)fromthehypothalamus.

Prolactin is a polypeptide hormone responsible for lactation, breast development, and hundreds of other actions needed to maintain homeostasis. The chemical structure of prolactin is similar to the structure of growth and placental lactogen hormones. Together, they form the "prolactin/growth hormone/placental lactogen" family, which is characterized by a conserved helix bundle protein composition. All hormones in this family derive from a common ancestral gene.

Prolactin is composed of 199 amino acids after the proteolytic cleavage of the signal peptide from the prolactin prohormone (pre-prolactin) and posttranslationally modified. It is common knowledge that the anterior pituitary synthesizes and secretes prolactin and dopamine-mediated hypothalamic regulation; however, the central nervous system, the immune system, the uterus, and the mam...