Comparison of the effect of VOSO4 | 合法醫療器材資訊網

由AMKordowiak著作·2007·被引用38次—ComparisonoftheeffectofVOSO4,Na3VO4andNaVO3onproliferation,viabilityandmorphologyofH35-19rathepatomacellline.PolJPathol.2007;58(1):51-7.

This study presents the investigation and comparison the influence of VOSO4 [V(IV)I, Na3VO4 and NaVO3 [V(V)] in the range of 0.5-20.0 microM on the rat hepatoma cell line H35-19. The cells were tested with crystal violet (N-hexamethylpararosaniline), and counted in a Bürker chamber to determine their rate of proliferation, while the survival level was established with neutral red and MTT [bromide 3-(4,5-dimetyltioazo-2)-2,5-diphenyl-tetrazole]. Parallel independent pathomorphological studies with electron microscopic examinations were done. We found progressive growth inhibition of rat hepatoma H35-19 cells within the range 0.5-20.0 concentrations of three vanadium salts. The most effective (and/or toxic) was NaVO3, whereas VOSO4 showed a relatively mild action. As compared with metavanadate or vanadyl sulphate and especially organic vanadium derivatives, previously studied by the same authors under similar expe...