Hyperbilirubinemia, Direct | 合法醫療器材資訊網

Conjugatedhyperbilirubinemiaisdefinedasameasureofdirectreactingbilirubinof>1.0mg/dL,ifthetotalserumbilirubin(TSB)is≤5.0mg/dL,ormore ...

Jaundice is the most common transitional finding in the newborn period, occurring in 60–70% of term and ∼80% of preterm infants. An elevation of serum bilirubin concentration >2 mg/dL is found in virtually all newborns in the first several days of life. Jaundice becomes clinically apparent at serum bilirubin concentration of ≥5 mg/dL.

Bilirubin is the end product of the catabolism of heme derived primarily from the breakdown of red blood cell hemoglobin. The rate-limiting step in this production is the oxidation of heme to form a green pigment called biliverdin, a process controlled by the enzyme heme oxygenase. Each molecule of heme catabolized results in equimolar quantities of bilirubin and carbon ...