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Interferon-GammaReleaseAssays(IGRAs)–BloodTestsforTBInfection.Whatarethey?...QuantiFERON®-TBGoldIn-Tubetest(QFT-GIT);;T-SPOT®.

Interferon-Gamma Release Assays (IGRAs) are whole-blood tests that can aid in diagnosing Mycobacterium tuberculosis infection. They do not help differentiate latent tuberculosis infection (LTBI) from tuberculosis disease. Two IGRAs that have been approved by the U.S. Food and Drug Administration (FDA) are commercially available in the U.S:

IGRAs measure a person’s immune reactivity to M. tuberculosis. White blood cells from most persons that have been infected with M. tuberculosis will release interferon-gamma (IFN-g) when mixed with antigens (substances that can produce an immune response) derived from M. tuberculosis.

To conduct the tests, fresh blood samples are mixed wit...