The influence of female sex hormones on nasal reactivity in ... | 合法醫療器材資訊網

由UPStübner著作·1999·被引用49次—Methods:Twenty-threeallergicwomenwithseasonalallergicrhinitisduetograsspollenwereincludedinthistrial.Twelveweretakingoralcontraceptives(OC) ...

Background: This study aimed to investigate whether the hormone peaks of estrogen and progesterone could influence the extent of the allergic reaction in grass-pollen-allergic women.

Methods: Twenty-three allergic women with seasonal allergic rhinitis due to grass pollen were included in this trial. Twelve were taking oral contraceptives (OC) (control group), and 11 were taking no pill (target group). The subjects were challenged with grass pollen by nasal provocation test around day 14 of their menstrual cycle (ovulation day) and again at the end of the cycle (day 27). The primary criteria were the subjective nasal symptoms rhinorrhea, nasal blockage, itching, and sneezing. A further criterion was the objectively measured nasal mucosal swelling, assessed by active anterior rhinomanometry. All criteria were evaluated before and 15 min after provocation, and the hormone status was determined on each ...