Automation and quality control in the coagulation laboratory | 合法醫療器材資訊網

由JMWalenga著作·1994·被引用22次—Hemostasisisabalancebetweencomplexinteractionsofdirectlyopposingsystems(coagulationandfibrinolysis)withseeminglyunrelatedsystemsatboth ...

Hemostasis is a balance between complex interactions of directly opposing systems (coagulation and fibrinolysis) with seemingly unrelated systems at both the enzymatic and cellular levels (platelets, endothelium, leukocytes). It should not be surprising that coagulation disorders often accompany many different disease states. Because the function of each protein involved in coagulation is now better defined, newer methodologies have been developed to assay them. In this regard, the hemostasis laboratory can take a two-step approach to diagnosis: global screening and targeted analysis. Several new global test systems provide more detailed, quantitative, and more physiologically relevant evaluations than earlier assays allowed. In addition, individual enzymes, inhibitors, cellular release products, and low molecular weight products of activation reactions (molecular markers) can now be measured in sensitive, specific ...