BNP or NT | 合法醫療器材資訊網

2019年9月24日—B-typenatriureticpeptide(BNP)andN-terminalpro-BNP(NT-proBNP)assistinthediagnosisofheartfailure(HF)andindeterminingpatient ...

B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) assist in the diagnosis of heart failure (HF) and in determining patient prognosis. In response to myocardial wall stretch, pre-proBNP is synthesized and processed to proBNP; which is further processed to the biologically inactive NT-proBNP fragment and the biologically active BNP fragment. Since BNP and NT-proBNP are elevated in patients with HF, both are useful adjuncts to clinical evaluation. In fact, the seminal studies for BNP and NT-proBNP demonstrated similar sensitivity and specificity for ruling in and ruling out HF. However, measurable concentrations of NT-proBNP are higher in plasma than BNP necessitating different clinical cut-points. For example, the accepted rule out cut-points for acute HF for BNP is 100 pg/mL and for NT-proBNP is 300 pg/mL. Subsequently, clinical guidelines give no direction to clinicians or laboratorians with regard...