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Indocyanine Green (ICG, known as Verdye, Diagnostic Green)

Indocyanine green (ICG) is a tricarbocyanine dye with both hydrophilic and lipophilic properties. Before administration, the powder must be reconstituted with water for injection.  Verdye is intended for intravenous injection (i.v.) via an injection needle, a central or peripheral catheter or cardiac catheter. Following I.V. administration, ICG is rapidly bound to plasma proteins, of which beta-apolipoprotein B is the principle carrier (95%) and remains in the blood vessels.

ICG is cleared exclusively through the liver, and then eliminated through the bile. It does not undergo metabolism.

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