Mixed Connective Tissue Disease. MCTD information | 合法醫療器材資訊網

2015年9月14日—Ithasbeenfurtherdefinedasaconditioninwhichthereareoverlappingfeaturesbetweentwoormoresystemicautoimmunediseasesinthe ...

Mixed connective tissue disease (MCTD) was first described as a distinct entity in 1972. The original condition was identified among a group of patients who had overlapping clinical features of systemic lupus erythematosus (SLE), scleroderma and myositis.

It has been further defined as a condition in which there are overlapping features between two or more systemic autoimmune diseases in the presence of anti-U1-ribonucleoprotein antibody (anti-U1-RNP Ab).1 Major advances in the immune pathogenesis of the disease have been made.2

MCTD should be distinguished from undifferentiated connective tissue disease (UCTD). In MCTD, there are features of multiple different connective tissue disorders. In UCTD, patients have features of a connective tissue disorder, but do not meet the diagnostic criteria for any specific condition.3

MCTD sometimes evolves into other connective tissue disorders, and, historically, the idea that MCTD is a distinct clinical entity has been critic...