Practical Considerations When Prescribing Icodextrin | 合法醫療器材資訊網
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Twenty years since the introduction of icodextrin in the United Kingdom in 1994, its use continues to expand to over 30,000 patients worldwide in more than 55 countries [1]. In the developed world, its penetration exceeds 50% [2]. This is despite increased costs associated with icodextrin compared to dextrose-based solutions.
Its success stems from its unique chemical properties that affect ultrafiltration (UF) and clearance. Icodextrin is a glucose polymer with a molecular weight of 16,800 Da resulting in a sustained colloid osmotic gradient. It is absorbed from the peritoneal cavity mainly via the lymphatic circulation, and the amount absorbed ranges from 20 to 40% for an 8-16 h dwell [3,4[1]]. Absorption also occurs at a slower rate than dextrose-based peritoneal dialysis (PD) solutions. Therefore, icodextrin can achieve a greater net UF during the long ...
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Metabolic and laboratory effects of icodextrin | 合法醫療器材資訊網
Metabolic and laboratory effects of icodextrin | 合法醫療器材資訊網
Peritoneal dialysis as a perpetuating cause of hyponatremia ... | 合法醫療器材資訊網
Practical Considerations When Prescribing Icodextrin | 合法醫療器材資訊網
Predictors of icodextrin induced hyponatremia | 合法醫療器材資訊網
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