Anesthesia and arrhythmogenesis in the chronic ... | 合法醫療器材資訊網
由ADunnink著作·2010·被引用23次—Anesthesiaandarrhythmogenesisinthechronicatrioventricularblockdog...(25microgxkg(-1)x5min(-1))twice:onceunderanesthesiaandonceawake.
Background: Drug-induced torsade de pointes (TdP) arrhythmias can readily be induced in anesthetized dogs with remodeled hearts [chronic complete atrioventricular block (CAVB) dogs]. Similar studies in conscious CAVB dogs reveal lower TdP incidences. Regulations forced us to reconsider our anesthetic regimen, which consist of pentobarbital followed by halothane (P + H). We investigated the relevance of anesthesia for this enhanced susceptibility (part 1) and compared 3 anesthetic regimens (part 2).
Methods: Part 1-Ten CAVB dogs paced from the high septum at 1000 milliseconds were challenged with dofetilide (25 microg x kg(-1) x 5 min(-1)) twice: once under anesthesia and once awake. Anesthesia consisted of P + H (n = 5) and thiopental maintained by isoflurane (T + I). Part 2-In CAVB dogs (n = 6) with spontaneous idioventricular rhythm, the electrophysiological and arrhythmogenic consequences of diff...
Anesthesia and arrhythmogenesis in the chronic ... | 合法醫療器材資訊網
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