Driving Pressure and Survival in the Acute Respiratory ... | 合法醫療器材資訊網

由MBPAmato著作·2015·被引用1602次—BackgroundMechanical-ventilationstrategiesthatuselowerend-inspiratory(plateau)airwaypressures,lowertidalvolumes(VT),andhigher ...

In univariate analyses in the derivation cohort, several significant associations were detected between independent predictor variables and survival (Table S3 in the Supplementary Appendix[1]). Two baseline variables (risk according to APACHE or SAPS and arterial pH) and two ventilator variables (FiO2 and ΔP) were significantly associated with survival after multivariate adjustment.

The test of this preliminary model in our first validation cohort showed that baseline PaO2:FiO2 could replace the information associated with the FiO2 variable (Table S7 in the Supplementary Appendix[2]), with the advantage of being externally validated.26 We also observed that age was a strong, independent predictor of survival even though it is a component of the APACHE score. After conservatively including the trial covariate, our final...