Use of Growth Hormone in the IVF Treatment of ... | 合法醫療器材資訊網

由RJHart著作·2019·被引用15次—GHhasbeenemployedforallwomenembarkingonIVFtreatment(16,17),...intracytoplasmicsperminjection,andintrafollicularsteroid, ...

Growth hormone (GH) is a peptide hormone secreted from the pituitary gland in response to growth hormone releasing hormone, and its secretion is inhibited by growth hormone inhibiting hormone (somatostatin) released form the hypothalamus into the hypophyseal portal system surrounding the pituitary gland. GH is released from the somatotroph cells of the anterior pituitary, with a frequency and amplitude that changes during the day. Its peak secretion occurs after sleep commences, and is age and sex dependent, with maximal secretion occurring around puberty, and its pulsatile release is further modulated by sleep patterns, diet, exercise and stress. As GH is not fat soluble; it exerts its effects via secondary messengers. The main end-point of GH activity is the liver, where GH leads to the synthesis of insulin- like growth factor 1 (IGF-1), which is consequently the major method of action of GH.

In the ovary IGF-1 receptors are present w...