A porcine xenograft | 合法醫療器材資訊網

由DNBracey著作·2019·被引用9次—Background:Xenograftsareanattractivealternativetotraditionalbonegraftsbecauseofthelargesupplyfromdonorswithpredictable ...

Background: Xenografts are an attractive alternative to traditional bone grafts because of the large supply from donors with predictable morphology and biology as well as minimal risk of human disease transmission. Clinical series involving xenograft bone transplantation, most commonly from bovine sources, have reported poor results with frequent graft rejection and failure to integrate with host tissue. Failures have been attributed to residual alpha-Gal epitope in the xenograft which humans produce natural antibody against. To the authors knowledge, there is currently no xenograft-derived bone graft substitute that has been adopted by orthopedic surgeons for routine clinical use.

Methods: In the current study, a bone scaffold intended to serve as a bone graft substitute was derived ...