Indications and Limitations of Bilayer Wound Matrix–Based Lo ... | 合法醫療器材資訊網

由SShakir著作·2020·被引用11次—Thesehighfailureandmorbidityratesareduetothepaucityofsofttissuein...ProductssuchasIntegrabilayerwoundmatrix(IntegraLifesciences, ...

Lower extremity wounds represent a heterogeneous and often complex clinical situation associated with high rates of failure and morbidity. These high failure and morbidity rates are due to the paucity of soft tissue in between the skin and bones of the lower extremity, which leads to frequent exposure and subsequent higher rates of osteomyelitis and limb amputation after wound development. The presence of common comorbidities, such as diabetes mellitus, peripheral arterial disease, bacterial colonization, impaired tissue perfusion, and venous insufficiency, further complicate healing. The economic burden associated with diabetic complications in the United States, for example, was $116 billion in 2007, with 33 percent of this cost attributed to neuropathic foot ulcers.1 Following limb amputation, the mortality rates for patients with and without diabetes are estimated to be 61 percent and 54.3 percent a...