Emergence of ceftazidimeavibactam resistance in KPC | 合法醫療器材資訊網
由SGöttig著作·2019·被引用29次—Ceftazidime/avibactamisavaluableantibioticagainstMDRandcarbapenem-resistantEnterobacterales.Basedontime-killkineticsaswellas ...
Objectives: The β-lactam/β-lactamase inhibitor combination ceftazidime/avibactam is active against KPC-producing Enterobacterales. Herein, we present molecular and phenotypic characterization of ceftazidime/avibactam resistance in KPC-3-producing Klebsiella pneumoniae that emerged in vivo and in vitro.
Methods: Sequence analysis of blaKPC-3 was performed from clinical and in vitro-generated ceftazidime/avibactam-resistant K. pneumoniae isolates. Time-kill kinetics and the Galleria mellonella infection model were applied to evaluate the activity of ceftazidime/avibactam and imipenem alone and in combination.
Results: The ceftazidime/avibactam-resistant clinical K. pneumoniae isolate revealed the amino acid change D179Y in KPC-3. Sixteen novel mutational changes in KPC-3 among in vitro-selected ceftazidime/avibactam-resistant isolates were described. Time-kill kinetics showed the ...
抗生素新藥ceftazidime | 合法醫療器材資訊網
贊飛得注射劑2 g0.5 g | 合法醫療器材資訊網
Ceftazidime | 合法醫療器材資訊網
Ceftazidime | 合法醫療器材資訊網
Ceftazidime-avibactam | 合法醫療器材資訊網
Emergence of ceftazidimeavibactam resistance in KPC | 合法醫療器材資訊網
Evaluation of the Synergy of Ceftazidime | 合法醫療器材資訊網
新藥介紹 | 合法醫療器材資訊網
Zavicefta 2 g0.5g powder for concentrate for solution for ... | 合法醫療器材資訊網
【"核通" 模擬攝影X光系統】許可證字號:衛署醫器輸字第010276號
器材品名:"核通"模擬攝影X光系統許可證字號:衛署醫器輸字第010276號註銷狀態:已註銷註銷日期:2019/12/13註銷理由:許可證已逾...
【生物梅里埃易特試梯度條抗生素感受性檢測 - 青黴烯類】許可證字號:衛署醫器輸字第018667號
器材品名:生物梅里埃易特試梯度條抗生素感受性檢測-青黴烯類許可證字號:衛署醫器輸字第018667號註銷狀態:註銷日期:註銷理由:...
【生物梅里埃易特試梯度條抗生素感受性檢測-Ceftolozane/Tazobactam】許可證字號:衛部醫器輸字第031810號
器材品名:生物梅里埃易特試梯度條抗生素感受性檢測-Ceftolozane/Tazobactam許可證字號:衛部醫器輸字第031810號註銷狀態:註銷...
【生物梅里埃易特試梯度條抗生素感受性檢測 - Ceftazidime/Avibactam】許可證字號:衛部醫器輸字第032492號
器材品名:生物梅里埃易特試梯度條抗生素感受性檢測-Ceftazidime/Avibactam許可證字號:衛部醫器輸字第032492號註銷狀態:註銷...