Bone Turnover Markers in the Diagnosis and Monitoring of ... | 合法醫療器材資訊網

由MBGreenblatt著作·2017·被引用135次—Boneturnovermarkers(BTMs)areaseriesofproteinorproteinderivativebiomarkersreleasedduringboneremodelingbyosteoblastsorosteoclasts.BTMscan ...

BACKGROUND

Disorders of bone metabolism, most notably osteoporosis, are highly prevalent and predispose to fractures, causing high patient morbidity and mortality. Diagnosis and monitoring of bone metabolic defects can present a major challenge as these disorders are largely asymptomatic and radiographic measures of bone mass respond slowly to changes in bone physiology.

CONTENT

Bone turnover markers (BTMs) are a series of protein or protein derivative biomarkers released during bone remodeling by osteoblasts or osteoclasts. BTMs can offer prognostic information on fracture risk that supplements radiographic measures of bone mass, but testing using BTMs has to take into account the large number of preanalytic factors and comorbid clinical conditions influencing BTM levels. BTMs respond rapidly to changes in bone physiology, therefore, they have utility in determining patient response to an...