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由吳思緯著作·2017—Objective：Oralsquamouscellcarcinoma(OSCC)isthemostcommonheadandneckmalignancy,thefourthmostcommoncanceramongmen,andthefifth ...

Objective：Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy, the fourth most common cancer among men, and the fifth leading cause of cancer deaths in Taiwan. Alcohol consumption, tobacco smoking, and betel quid chewing are the main known environmental risk factors of oral cancer. MACC1 (Metastasis-Associated in Colon Cancer 1), a novel identified oncogene and a key regulator of the HGF/Met signal pathway, has been demonstrated that plays an crucial role in malignant progression of many cancer, including colorectal, gastric, hepatic, pancreatic, lung, breast, esophageal cacner and head & neck cancer. The overexpression of MACC1 not only lead to abnormal activation of the HGF/Met signal pathway and promotes cell proliferation, migration, tumor invasion, angiogenesis and metastasis but has been regarded as a novel tumor marker in recent years. However, the association between MACC1 and oral ...