Sensitive and non | 合法醫療器材資訊網

由KSEom著作·2020·被引用15次—Anon-invasive,painlessmethodofdeterminingthecholesterollevelinbloodwouldimprovetheuser'sconvenience.Toproviderapidand ...

An excessive cholesterol level can lead to cardiovascular diseases, such as stroke, hypertension, and myocardial infarction. A non-invasive, painless method of determining the cholesterol level in blood would improve the users convenience. To provide rapid and accurate determination of cholesterol, we have developed a simple, disposable, enzyme-based electrochemical biosensor that can detect salivary cholesterol. It is possible to detect low concentrations of cholesterol in saliva using the optimized vertical structure of the platinum nano-cluster (Pt-NC) and the immobilization of a proper volume of an enzyme. The biosensor exhibited a linear range from 2 to 486 μM, the limit of detection was about 2 μM, and the sensitivity of the sensor was calculated to be 132 μA mM-1 cm-2. It also showed good specificity for ascorbic acid, uric acid, dopamine, glucose, and lactate. In a test with an actual sample, the performance of the bios...