Strategies for Helicobacter pylori eradication in the year 2020 | 合法醫療器材資訊網

由RPellicano著作·2020·被引用5次—Duringthelasttwodecades,severalmultidrugregimensconsistingofaprotonpumpinhibitor(PPI)andtwoorthreeantibiotics,havebeen ...

During the last two decades, several multidrug regimens consisting of a proton pump inhibitor (PPI) and two or three antibiotics, have been used to treat Helicobacter pylori (H. pylori) infection.[1]

However, over time, an increased failure rate of standard eradication treatment, in particular for clarithromycin-based regimens, has been reported worldwide with eradication rates falling to unacceptable levels.[2] To highlight the concerns caused by the increasing resistance of H. pylori to antibiotics, in particular to clarithromycin, the World Health Organization added this microorganism in the priority list for research and development of new antibiotics.[3]

Mechanistically, we have learned that the bacteria develop four main barriers to antibiotics that are prevention of cell penetration, modification of the target, enzymatic inactivation of the antibiotic, and elimination via efflux pumps. Modification of the target is the main mechanism of H. pylori...