The role of CD45 and CD45 | 合法醫療器材資訊網
由JGAltin著作·1997·被引用214次—CD45(lymphocytecommonantigen)isareceptor-linkedproteintyrosinephosphatasethatisexpressedonallleucocytes,andwhichplaysacrucialroleinthe ...
CD45 (lymphocyte common antigen) is a receptor-linked protein tyrosine phosphatase that is expressed on all leucocytes, and which plays a crucial role in the function of these cells. On T cells the extracellular domain of CD45 is expressed in several different isoforms, and the particular isoform(s) expressed depends on the particular subpopulation of cell, their state of maturation, and whether or not they have previously been exposed to antigen. It has been established that the expression of CD45 is essential for the activation of T cells via the TCR, and that different CD45 isoforms display a different ability to support T cell activation. Although the tyrosine phosphatase activity of the intracellular region of CD45 has been shown to be crucial for supporting signal transduction from the TCR, the nature of the ligands for the different isoforms of CD45 have been elusive. Moreover, the precise mechanism by which ...
CD4, CD8 and the role of CD45 in T | 合法醫療器材資訊網
CD45 functions as a signaling gatekeeper in T cells | 合法醫療器材資訊網
CD45 functions as a signaling gatekeeper in T cells | 合法醫療器材資訊網
CD45 isoform expression during T cell development in the ... | 合法醫療器材資訊網
CD45 isoforms in T cell signalling and development | 合法醫療器材資訊網
CD45 modulates T cell receptorCD3 | 合法醫療器材資訊網
CD45 | 合法醫療器材資訊網
The role of CD45 and CD45 | 合法醫療器材資訊網
The role of CD45 in T-cell activation | 合法醫療器材資訊網
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