Seprafilm® adhesion barrier | 合法醫療器材資訊網

由MPDiamond著作·2012·被引用69次—Seprafilmisabioresorbablemembranecomposedofsodiumhyaluronate(HA)andcarboxymethylcellulose(CMC)whichhavebeenchemicallymodifiedto ...

The safe and effective use of Seprafilm in the abdominal cavity of animals has been reported in a number of publications using multiple species and models of abdominal surgery [4–34]. In these models, the use of Seprafilm was reported to be efficacious in reducing adhesions, including in the presence of blood and irrigation solution [4], in combination with melatonin [33] and under ischemic conditions [4]. When used in multiple layers [4], Seprafilm did not adversely affect wound healing [4, 6, 8, 35], did not affect anastomotic healing with [36] or without concomitant ischemia [35, 37], and did not potentiate intra-abdominal sepsis [11, 38]. In general, Seprafilm use has been reported not to have adverse effects [5, 7, 9, 10, 12, 13, 39–41]. Concomitant radiotherapy did not alter the efficacy [42]; however, the efficacy of Seprafilm was reduced in the presence of peritonitis [43].

In addition, the use of Seprafilm in an...