原發性自體免疫溶血性貧血的疾病改善療法- Liu, A | 合法醫療器材資訊網

2021年3月31日—本篇文獻回顧的目的是想找出哪些研究告訴我們治療原發性AIHA免疫調節劑的安全性和有效性。免疫調節劑會改變免疫系統的運作方式，它們無法 ...

Both included studied compared rituximab plus corticosteroid compared with corticosteroid alone (+/‐ placebo) and were combined in a meta‐analysis. All effect sizes were calculated with the fixed‐effect model unless otherwise specified. See summary of findings Table 1[1] for further details.

Frequency of complete haematological response (defined as normalisation of haemoglobin (Hb) concentration, reticulocyte (immature red blood cells (RBCs)) count, and indirect (or unconjugated] bilirubin level) at months two, six and 12.

Compared with glucocorticoid alone, the evidence is very uncertain about the effect of adding rituximab to glucocorticoids on complete haematological response at six months (n = 64, study = 1; RR 1.73, 95% CI 0.99 to 3.02; participants = 64; RR and CI calculated by review authors; GRADE very low certainty), but it may result in a large increase of complete r...