Retinitis pigmentosa | 合法醫療器材資訊網

Retinitispigmentosa(RP)isageneticdisorderoftheeyesthatcauseslossofvision.Symptomsincludetroubleseeingatnightanddecreasedperipheralvision ...

Gradual retinal degeneration leading to progressive sight loss

Medical condition

Retinitis pigmentosa (RP) is a genetic disorder of the eyes that causes loss of vision.[1] Symptoms include trouble seeing at night and decreasing peripheral vision (side and upper or lower visual field).[1] As peripheral vision worsens, people may experience "tunnel vision".[1] Complete blindness is uncommon.[2] Onset of symptoms is generally gradual and often begins in childhood.[1][2]

Retinitis pigmentosa is generally inherited from one or both parents.[3] It is caused by genetic variants in nearly 100 genes.[3] The underlying mechanism involves the progressive loss of rod photoreceptor cells that line the retina of the eyeball.[1] The rod cells secrete a neuroprotective substance (Rod-derived cone viability factor, RdCVF) that protects the cone cells from apoptosis (cell death). However...