Serum prolactin concentration at presentation of non ... | 合法醫療器材資訊網

由LABehan著作·2013·被引用17次—Serumprolactinconcentrationatpresentationofnon-functioningpituitarymacroadenomas.JEndocrinolInvest.Jul-Aug2013;36(7):508-14.doi:10.3275/​8815.

Objective: Serum PRL levels at presentation may be useful in distinguishing between disconnection hyperprolactinemia in non-secretory pituitary adenomas and prolactinomas in order to guide appropriate therapy; however, there is a debate regarding the discriminatory PRL thresholds. We aimed to examine PRL concentrations at presentation in a cohort of histologically proven non-functioning pituitary adenomas (NFPA).

Design and methods: Retrospective case note analysis was performed. Clinical, biochemical, histopathological and radiological data were recorded and analyzed. Complete data were available for 250 subjects with NFPA.

Results: Of the study population, 44.8% were hyperprolactinemic at presentation, 55.3% of whom were female. Of those with hyperprolactinemia, 73.2% had PRL<1000 mIU/l on presentation, 24.1% had PRL between 1000 and 1999 mIU/l. Only 2.7% (no.=3 females, 1.2% ...