Comparison of hemostatic agents used in vascular surgery | 合法醫療器材資訊網

Fibrin sealants, also called fibrin glue, are derived from human and/or animal blood products, which imitate the final stages of the coagulation cascade in the formation of a fibrin clot. A combination of a freeze-dried clotting protein (primarily fibrinogen) and thrombin is contained in separate vials and interacts during application to form a stable clot. The preparation and application of fibrin glue is somewhat complicated; fibrinogen must be dissolved in sterile water, while thrombin must be dissolved in a dilute CaCl2 solution. Subsequently, the two solutions are loaded into a double-barreled syringe that facilitates their combination as they are applied. Some sealants contain two additional ingredients: human blood factor XIII, which strengthens blood clots, and aprotinin, extracted from bovine lung, which inhibits the enzymes that degrade blood clots.